Credentialing Preclinical Pediatric Xenograft Models Using Gene Expression and Tissue Microarray Analysis

Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis.

Human tumor xenografts have been used extensively for rapid screening of the efficacy of anticancer drugs for the past 35 years. The selection of appropriate xenograft models for drug testing has been largely empirical and has not incorporated a similarity to the tumor type of origin at the molecular level. This study is the first comprehensive analysis of the transcriptome of a large set of pe...

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Gene Expression and Tissue Microarray Analysis Credentialing Preclinical Pediatric Xenograft Models Using

Human tumor xenografts have been used extensively for rapid screening of the efficacy of anticancer drugs for the past 35 years. The selection of appropriate xenograft models for drug testing has been largely empirical and has not incorporated a similarity to the tumor type of origin at the molecular level. This study is the first comprehensive analysis of the transcriptome of a large set of pe...

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Cancerous Tissue Classification Using Microarray Gene Expression

In this project, we apply machine learning techniques to perform tumor vs. normal tissue classification using gene expression microarray data, which was proven to be useful for early-stage cancer diagnosis and cancer subtype identification. We compare the results of both supervised learning (k-nearest-neighbors, SVMs, boosting) and unsupervised learning (k-means clustering, hierarchical cluster...

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Global gene expression analysis using microarray to study differential vulnerability to neurodegeneration

Neurodegenerative disorders such as Parkinson’s disease, motor neuron disease and Alzheimer’s disease is characterized by loss of specific cells within certain regions of the brain. One of the most compelling questions is to determine why specific cell populations are vulnerable to neurodegeneration. We addressed this question by studying global gene expression changes using an animal model of ...

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Global gene expression analysis using microarray to study differential vulnerability to neurodegeneration

Neurodegenerative disorders such as Parkinson’s disease, motor neuron disease and Alzheimer’s disease is characterized by loss of specific cells within certain regions of the brain. One of the most compelling questions is to determine why specific cell populations are vulnerable to neurodegeneration. We addressed this question by studying global gene expression changes using an animal model of ...

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Credentialing Preclinical Pediatric Xenograft Models Using Gene Expression and Tissue Microarray Analysis

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